Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

The relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other om...

Full description

Bibliographic Details
Main Authors: Daniel Wilinski, Jasmine Winzeler, William Duren, Jenna L. Persons, Kristina J. Holme, Johan Mosquera, Morteza Khabiri, Jason M. Kinchen, Peter L. Freddolino, Alla Karnovsky, Monica Dus
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11933-z
id doaj-39a24afdb8f8444a919857be1f66c998
record_format Article
spelling doaj-39a24afdb8f8444a919857be1f66c9982021-05-11T12:04:46ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11933-zRapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogasterDaniel Wilinski0Jasmine Winzeler1William Duren2Jenna L. Persons3Kristina J. Holme4Johan Mosquera5Morteza Khabiri6Jason M. Kinchen7Peter L. Freddolino8Alla Karnovsky9Monica Dus10Department of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the ArtsDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the ArtsDepartment of Computational Medicine and Bioinformatics, The University of Michigan Medical SchoolDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the ArtsGraduate Program in Molecular & Integrative Physiology, The University of Michigan Medical SchoolDepartment of Computational Medicine and Bioinformatics, The University of Michigan Medical SchoolDepartment of Biological Chemistry, The University of Michigan Medical SchoolMetabolon, IncDepartment of Computational Medicine and Bioinformatics, The University of Michigan Medical SchoolDepartment of Computational Medicine and Bioinformatics, The University of Michigan Medical SchoolDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the ArtsThe relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data.https://doi.org/10.1038/s41467-019-11933-z
collection DOAJ
language English
format Article
sources DOAJ
author Daniel Wilinski
Jasmine Winzeler
William Duren
Jenna L. Persons
Kristina J. Holme
Johan Mosquera
Morteza Khabiri
Jason M. Kinchen
Peter L. Freddolino
Alla Karnovsky
Monica Dus
spellingShingle Daniel Wilinski
Jasmine Winzeler
William Duren
Jenna L. Persons
Kristina J. Holme
Johan Mosquera
Morteza Khabiri
Jason M. Kinchen
Peter L. Freddolino
Alla Karnovsky
Monica Dus
Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
Nature Communications
author_facet Daniel Wilinski
Jasmine Winzeler
William Duren
Jenna L. Persons
Kristina J. Holme
Johan Mosquera
Morteza Khabiri
Jason M. Kinchen
Peter L. Freddolino
Alla Karnovsky
Monica Dus
author_sort Daniel Wilinski
title Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
title_short Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
title_full Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
title_fullStr Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
title_full_unstemmed Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
title_sort rapid metabolic shifts occur during the transition between hunger and satiety in drosophila melanogaster
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description The relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data.
url https://doi.org/10.1038/s41467-019-11933-z
work_keys_str_mv AT danielwilinski rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT jasminewinzeler rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT williamduren rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT jennalpersons rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT kristinajholme rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT johanmosquera rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT mortezakhabiri rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT jasonmkinchen rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT peterlfreddolino rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT allakarnovsky rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
AT monicadus rapidmetabolicshiftsoccurduringthetransitionbetweenhungerandsatietyindrosophilamelanogaster
_version_ 1721445461800255488