Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers

Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers

<p>Abstract</p> <p>Background</p> <p>Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified. Likewise, disruption of the TSC1/TSC2 complex through loss of TSC1 or...

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Bibliographic Details
Main Authors: Nikitakis Nikolaos G, Ord Robert A, Parashar Pallavi, Norris Kathleen, Hebert Carla, Sauk John J
Format: Article
Language:English
Published: BMC 2006-01-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/5/1/3

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