Chromatin conformation regulates the coordination between DNA replication and transcription

Chromatin conformation regulates the coordination between DNA replication and transcription

The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA replication and consequences on replicative stress.

Bibliographic Details
Main Authors: Ricardo Almeida, José Miguel Fernández-Justel, Cristina Santa-María, Jean-Charles Cadoret, Laura Cano-Aroca, Rodrigo Lombraña, Gonzalo Herranz, Alessandra Agresti, María Gómez
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03539-8
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spelling doaj-399d7ceb0c43497db1da7ece90fc06c82021-05-11T10:13:40ZengNature Publishing GroupNature Communications2041-17232018-04-019111410.1038/s41467-018-03539-8Chromatin conformation regulates the coordination between DNA replication and transcriptionRicardo Almeida0José Miguel Fernández-Justel1Cristina Santa-María2Jean-Charles Cadoret3Laura Cano-Aroca4Rodrigo Lombraña5Gonzalo Herranz6Alessandra Agresti7María Gómez8Functional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)Functional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)Functional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)Institut Jacques Monod, CNRS-Université Paris DiderotFunctional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)Functional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)Functional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)San Raffaele Scientific InstituteFunctional Organization of the Genome Group, Centro de Biología Molecular Severo Ochoa CBMSO (CSIC/UAM)The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA replication and consequences on replicative stress.https://doi.org/10.1038/s41467-018-03539-8
collection DOAJ
language English
format Article
sources DOAJ
author Ricardo Almeida
José Miguel Fernández-Justel
Cristina Santa-María
Jean-Charles Cadoret
Laura Cano-Aroca
Rodrigo Lombraña
Gonzalo Herranz
Alessandra Agresti
María Gómez
spellingShingle Ricardo Almeida
José Miguel Fernández-Justel
Cristina Santa-María
Jean-Charles Cadoret
Laura Cano-Aroca
Rodrigo Lombraña
Gonzalo Herranz
Alessandra Agresti
María Gómez
Chromatin conformation regulates the coordination between DNA replication and transcription
Nature Communications
author_facet Ricardo Almeida
José Miguel Fernández-Justel
Cristina Santa-María
Jean-Charles Cadoret
Laura Cano-Aroca
Rodrigo Lombraña
Gonzalo Herranz
Alessandra Agresti
María Gómez
author_sort Ricardo Almeida
title Chromatin conformation regulates the coordination between DNA replication and transcription
title_short Chromatin conformation regulates the coordination between DNA replication and transcription
title_full Chromatin conformation regulates the coordination between DNA replication and transcription
title_fullStr Chromatin conformation regulates the coordination between DNA replication and transcription
title_full_unstemmed Chromatin conformation regulates the coordination between DNA replication and transcription
title_sort chromatin conformation regulates the coordination between dna replication and transcription
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA replication and consequences on replicative stress.
url https://doi.org/10.1038/s41467-018-03539-8
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AT josemiguelfernandezjustel chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT cristinasantamaria chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT jeancharlescadoret chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT lauracanoaroca chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT rodrigolombrana chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT gonzaloherranz chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT alessandraagresti chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
AT mariagomez chromatinconformationregulatesthecoordinationbetweendnareplicationandtranscription
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