Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B

Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B

Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter‐ and intrapatient heterogeneity is a hallmark of GBM, with epigenetically distinct cancer stem‐like cells (CSCs) at the apex. Targeting GSCs remains a challenging task because of their uniq...

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Bibliographic Details
Main Authors: Mikkel Staberg, Rikke Darling Rasmussen, Signe Regner Michaelsen, Henriette Pedersen, Kamilla Ellermann Jensen, Mette Villingshøj, Jane Skjoth‐Rasmussen, Jannick Brennum, Kristoffer Vitting‐Seerup, Hans Skovgaard Poulsen, Petra Hamerlik
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Molecular Oncology
Subjects:
cancer stem‐like cell
chemoresistance
epigenetics
glioblastoma
histone demethylase
Online Access:https://doi.org/10.1002/1878-0261.12174

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