Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties. The considered fragments were based on either <i>N-</i>acylhydrazone (...

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Bibliographic Details
Main Authors: Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, Aleksandra Misicka
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
analgesics
cytotoxic activity
diacylhydrazine
µ-opioid receptor
multitarget compounds
<i>N’</i>-acylhydrazide
Online Access:https://www.mdpi.com/1420-3049/25/15/3429

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https://www.mdpi.com/1420-3049/25/15/3429

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