The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease

The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease

Abstract With glucose being the preferred source of energy in activated T cells, targeting glycolysis has become an attractive therapeutic intervention point for chronic inflammatory bowel diseases (IBD). The switch to glycolysis is mediated by phosphoinositide‐3‐kinases (PI3K) which relay signals f...

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Bibliographic Details
Main Authors: Paula Winkelmann, Anna‐Lena Unterweger, Diya Khullar, Florian Beigel, Leandra Koletzko, Matthias Siebeck, Roswitha Gropp
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Immunity, Inflammation and Disease
Subjects:
copanlisib
immune‐metabolism
inflammatory bowel disease
NSG‐UC mouse model
PI3K
ulcerative colitis
Online Access:https://doi.org/10.1002/iid3.435

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