Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05763-8 |
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doaj-397f4e630bac42c587fdf199a5689e3f |
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doaj-397f4e630bac42c587fdf199a5689e3f2021-05-11T10:09:16ZengNature Publishing GroupNature Communications2041-17232018-08-019111410.1038/s41467-018-05763-8Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapySusan E. Logue0Eoghan P. McGrath1Patricia Cleary2Stephanie Greene3Katarzyna Mnich4Aitor Almanza5Eric Chevet6Róisín M. Dwyer7Anup Oommen8Patrick Legembre9Florence Godey10Emma C. Madden11Brian Leuzzi12Joanna Obacz13Qingping Zeng14John B. Patterson15Richard Jäger16Adrienne M. Gorman17Afshin Samali18Apoptosis Research Centre, National University of Ireland GalwayApoptosis Research Centre, National University of Ireland GalwayApoptosis Research Centre, National University of Ireland GalwayFosun Orinove PharmaTech Inc.Apoptosis Research Centre, National University of Ireland GalwayApoptosis Research Centre, National University of Ireland GalwayInserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1LAM 2015, Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland GalwaySchool of Natural Sciences, National University of Ireland GalwayInserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1Inserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1Apoptosis Research Centre, National University of Ireland GalwayApoptosis Research Centre, National University of Ireland GalwayInserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1Fosun Orinove PharmaTech Inc.Fosun Orinove PharmaTech Inc.Hochschule Bonn-Rhein-Sieg, University of Applied Sciences, Department of Natural SciencesApoptosis Research Centre, National University of Ireland GalwayApoptosis Research Centre, National University of Ireland GalwayIRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.https://doi.org/10.1038/s41467-018-05763-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali |
| spellingShingle |
Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Nature Communications |
| author_facet |
Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali |
| author_sort |
Susan E. Logue |
| title |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_short |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_full |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_fullStr |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_full_unstemmed |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_sort |
inhibition of ire1 rnase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC. |
| url |
https://doi.org/10.1038/s41467-018-05763-8 |
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