The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions.

The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions.

Gastric cancer grows under a hypoxic environment. HIF-1α is known to play an important role in controlling the production of reactive oxygen species (ROS) in the mitochondria under hypoxic conditions. We previously established HIF-1α knockdown (KD) cells and control (SC) cells in the 58As9 gastric c...

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Main Authors: Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4560388?pdf=render

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