Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative lo...

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Bibliographic Details
Main Authors: Ariadna Bargiela, Estefanía Cerro-Herreros, Juan M. Fernandez-Costa, Juan J. Vilchez, Beatriz Llamusi, Ruben Artero
Format: Article
Language:English
Published: The Company of Biologists 2015-07-01
Series:Disease Models & Mechanisms
Subjects:
Autophagy
Apoptosis
Muscleblind
CTG repeat expansion
Muscle atrophy
Dystrophy
Online Access:http://dmm.biologists.org/content/8/7/679

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