A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy

A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy

The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extra...

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Main Authors: Lalitha Nayak, Alvin H. Schmaier
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2012/948351
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spelling doaj-395842cc9b3644fb8dcd07e834fae5d32020-11-24T21:39:48ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/948351948351A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen TherapyLalitha Nayak0Alvin H. Schmaier1Seidman Cancer Center, University Hospitals Case Medical Center and Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, WRB2-130, Cleveland, OH 44106-7284, USASeidman Cancer Center, University Hospitals Case Medical Center and Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, WRB2-130, Cleveland, OH 44106-7284, USAThe antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function.http://dx.doi.org/10.1155/2012/948351
collection DOAJ
language English
format Article
sources DOAJ
author Lalitha Nayak
Alvin H. Schmaier
spellingShingle Lalitha Nayak
Alvin H. Schmaier
A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
Case Reports in Hematology
author_facet Lalitha Nayak
Alvin H. Schmaier
author_sort Lalitha Nayak
title A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_short A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_full A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_fullStr A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_full_unstemmed A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_sort platelet acquired storage pool disorder associated with tamoxifen therapy
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2012-01-01
description The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function.
url http://dx.doi.org/10.1155/2012/948351
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AT lalithanayak plateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy
AT alvinhschmaier plateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy
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