An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon
Studies using animal models have demonstrated that ingestion of bovine lactoferrin (bLF) is able to induce cytokine expression in the intestine and inhibit carcinogenesis in the colon and other organs of experimental animals. Consequently, a clinical trial was conducted in the National Cancer Center...
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2014-09-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614002278 |
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doaj-3953ee99962144bca47a40ffe32bf9fc2021-04-29T04:42:50ZengElsevierJournal of Functional Foods1756-46462014-09-0110305317An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colonDavid B. Alexander0Masaaki Iigo1Hirokazu Hamano2Takahiro Kozu3Yutaka Saito4Daizo Saito5Tadao Kakizoe6Jiegou Xu7Koji Yamauchi8Mitsunori Takase9Masumi Suzui10Hiroyuki Tsuda11Nanotoxicology Project, Nagoya City University, Nagoya, Japan; Department of Molecular Toxicology, Nagoya City University, Nagoya, Japan; Corresponding author. Tel.: +81 528363496; fax: +81 528363497.Nanotoxicology Project, Nagoya City University, Nagoya, Japan; Department of Molecular Toxicology, Nagoya City University, Nagoya, JapanNutritional Science Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanToyosu Cubic Garden Kozu Clinic, 1F, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Department, Nihonbashi DAIZO Clinic, Tokyo, JapanJapan Cancer Society, Tokyo, JapanNanotoxicology Project, Nagoya City University, Nagoya, Japan; Department of Molecular Toxicology, Nagoya City University, Nagoya, JapanFood Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanNutritional Science Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanDepartment of Molecular Toxicology, Nagoya City University, Nagoya, JapanNanotoxicology Project, Nagoya City University, Nagoya, JapanStudies using animal models have demonstrated that ingestion of bovine lactoferrin (bLF) is able to induce cytokine expression in the intestine and inhibit carcinogenesis in the colon and other organs of experimental animals. Consequently, a clinical trial was conducted in the National Cancer Center Hospital, Tokyo, Japan to determine whether ingestion of bLF affected the growth of colorectal polyps in humans. The Tokyo-trial found that ingestion of 3.0 g bLF suppressed the growth of colorectal polyps and increased the level of serum human lactoferrin in participants 63 years old or younger. The present study is a complementary study to the Tokyo-trial to determine if a change in the expression of one or more cytokines could be detected in the colon of the Tokyo-trial participants after ingesting bLF. We found that daily ingestion of 3.0 g bLF promoted the expression of interferon alpha in the colon of the Tokyo-trial participants.http://www.sciencedirect.com/science/article/pii/S1756464614002278Ingestion of bovine lactoferrinHuman interferon alphaHuman intestine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
David B. Alexander Masaaki Iigo Hirokazu Hamano Takahiro Kozu Yutaka Saito Daizo Saito Tadao Kakizoe Jiegou Xu Koji Yamauchi Mitsunori Takase Masumi Suzui Hiroyuki Tsuda |
| spellingShingle |
David B. Alexander Masaaki Iigo Hirokazu Hamano Takahiro Kozu Yutaka Saito Daizo Saito Tadao Kakizoe Jiegou Xu Koji Yamauchi Mitsunori Takase Masumi Suzui Hiroyuki Tsuda An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon Journal of Functional Foods Ingestion of bovine lactoferrin Human interferon alpha Human intestine |
| author_facet |
David B. Alexander Masaaki Iigo Hirokazu Hamano Takahiro Kozu Yutaka Saito Daizo Saito Tadao Kakizoe Jiegou Xu Koji Yamauchi Mitsunori Takase Masumi Suzui Hiroyuki Tsuda |
| author_sort |
David B. Alexander |
| title |
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| title_short |
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| title_full |
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| title_fullStr |
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| title_full_unstemmed |
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| title_sort |
ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon |
| publisher |
Elsevier |
| series |
Journal of Functional Foods |
| issn |
1756-4646 |
| publishDate |
2014-09-01 |
| description |
Studies using animal models have demonstrated that ingestion of bovine lactoferrin (bLF) is able to induce cytokine expression in the intestine and inhibit carcinogenesis in the colon and other organs of experimental animals. Consequently, a clinical trial was conducted in the National Cancer Center Hospital, Tokyo, Japan to determine whether ingestion of bLF affected the growth of colorectal polyps in humans. The Tokyo-trial found that ingestion of 3.0 g bLF suppressed the growth of colorectal polyps and increased the level of serum human lactoferrin in participants 63 years old or younger. The present study is a complementary study to the Tokyo-trial to determine if a change in the expression of one or more cytokines could be detected in the colon of the Tokyo-trial participants after ingesting bLF. We found that daily ingestion of 3.0 g bLF promoted the expression of interferon alpha in the colon of the Tokyo-trial participants. |
| topic |
Ingestion of bovine lactoferrin Human interferon alpha Human intestine |
| url |
http://www.sciencedirect.com/science/article/pii/S1756464614002278 |
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