Very Early Involvement of Innate Immunity in Peripheral Nerve Degeneration in SOD1-G93A Mice

Very Early Involvement of Innate Immunity in Peripheral Nerve Degeneration in SOD1-G93A Mice

Recent preclinical and clinical evidence suggest that immune system has a role in the progression and prognosis of Amyotrophic Lateral Sclerosis (ALS), but the identification of a clear mechanism and immune players remains to be elucidated. Here, we have investigated, in 30 and 60 days (presymptomat...

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Bibliographic Details
Main Authors: Daniela Francesca Angelini, Federica De Angelis, Valentina Vacca, Eleonora Piras, Chiara Parisi, Michele Nutini, Alida Spalloni, Francesca Pagano, Patrizia Longone, Luca Battistini, Flaminia Pavone, Sara Marinelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
peripheral nerve degeneration
demyelination
amyotrophic lateral sclerosis
mast cells
pro-inflammatory cytokine
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.575792/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.575792/full

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