Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.

Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.

Herpes simplex virus type 1 (HSV-1) and HSV-2 are highly prevalent viruses that cause a variety of diseases, from cold sores to encephalitis. Both viruses establish latency in peripheral neurons but the molecular mechanisms facilitating the infection of neurons are not fully understood. Using surfac...

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Bibliographic Details
Main Authors: Jorge Rubén Cabrera, Abel Viejo-Borbolla, Nadia Martinez-Martín, Soledad Blanco, Francisco Wandosell, Antonio Alcamí
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4303327?pdf=render

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http://europepmc.org/articles/PMC4303327?pdf=render

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