Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance

Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance

Tyrosine kinase inhibitors are a class of chemotherapeutic drugs that target specific protein kinases. These tyrosine kinase inhibitors constitute a relatively new class of drugs which target for instance Bcr-Abl, Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Recepto...

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Bibliographic Details
Main Authors: Daniel J. de Klerk, Richard J. Honeywell, Gerrit Jansen, Godefridus J. Peters
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
tyrosine kinase inhibitors
multidrug resistance
ABC transporters
lysosomes
Online Access:https://www.mdpi.com/2072-6694/10/12/503

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