CONSTRUCTION OF IN SILICO STRUCTURE-BASED SCREENING TOOLS TO STUDY THE OXIDATIVE METABOLITES FORMATION OF CURCUMIN BY HUMAN CYTOCHROME 450 3A4

CONSTRUCTION OF IN SILICO STRUCTURE-BASED SCREENING TOOLS TO STUDY THE OXIDATIVE METABOLITES FORMATION OF CURCUMIN BY HUMAN CYTOCHROME 450 3A4

Cytochrome P450 3A4 (CYP3A4) is a phase 1 metabolism enzyme which is responsible for the metabolism of about 3040% drug in the market. This CYP3A4 is the most abundant CYP450 expressed in human body and also the one who is responsible for the biotransformation of most drugs. The competitive inhibiti...

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Bibliographic Details
Main Authors: Dewi Setyaningsih, Muhammad Radifar, Yosi Bayu Murti, Enade Perdana Istyastono
Format: Article
Language:English
Published: Universitas Gadjah Mada 2013-04-01
Series:Indonesian Journal of Pharmacy
Subjects:
site of metabolism (SOM)
curcumin
biotransformation
in silico
molecular docking
protein-ligand interaction fingerprinting
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/544/422

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