In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila

In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila

In Drosophila, transcription is thought to be required for TAD formation, while the role of architectural proteins remains controversial. Here, the authors find that deletion of domain boundaries at the fly Notch locus results in TAD fusion and long-range topological defects, loss of architectural p...

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Bibliographic Details
Main Authors: Rodrigo G. Arzate-Mejía, Angel Josué Cerecedo-Castillo, Georgina Guerrero, Mayra Furlan-Magaril, Félix Recillas-Targa
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14651-z
Description
Summary:In Drosophila, transcription is thought to be required for TAD formation, while the role of architectural proteins remains controversial. Here, the authors find that deletion of domain boundaries at the fly Notch locus results in TAD fusion and long-range topological defects, loss of architectural protein and RNA Pol II chromatin binding, and transcription defects.
ISSN:2041-1723

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