NMR-Based Metabolomics in Metal-Based Drug Research

Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. I...

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Main Authors: Federica De Castro, Michele Benedetti, Laura Del Coco, Francesco Paolo Fanizzi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/12/2240
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spelling doaj-393659e6a01e4bbcb41a7386b8af6bad2020-11-25T01:52:00ZengMDPI AGMolecules1420-30492019-06-012412224010.3390/molecules24122240molecules24122240NMR-Based Metabolomics in Metal-Based Drug ResearchFederica De Castro0Michele Benedetti1Laura Del Coco2Francesco Paolo Fanizzi3Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyThanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments.https://www.mdpi.com/1420-3049/24/12/2240metabolomic<sup>1</sup>H NMR Spectroscopyantitumour drugsmetal drugsplatinum drugs
collection DOAJ
language English
format Article
sources DOAJ
author Federica De Castro
Michele Benedetti
Laura Del Coco
Francesco Paolo Fanizzi
spellingShingle Federica De Castro
Michele Benedetti
Laura Del Coco
Francesco Paolo Fanizzi
NMR-Based Metabolomics in Metal-Based Drug Research
Molecules
metabolomic
<sup>1</sup>H NMR Spectroscopy
antitumour drugs
metal drugs
platinum drugs
author_facet Federica De Castro
Michele Benedetti
Laura Del Coco
Francesco Paolo Fanizzi
author_sort Federica De Castro
title NMR-Based Metabolomics in Metal-Based Drug Research
title_short NMR-Based Metabolomics in Metal-Based Drug Research
title_full NMR-Based Metabolomics in Metal-Based Drug Research
title_fullStr NMR-Based Metabolomics in Metal-Based Drug Research
title_full_unstemmed NMR-Based Metabolomics in Metal-Based Drug Research
title_sort nmr-based metabolomics in metal-based drug research
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-06-01
description Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments.
topic metabolomic
<sup>1</sup>H NMR Spectroscopy
antitumour drugs
metal drugs
platinum drugs
url https://www.mdpi.com/1420-3049/24/12/2240
work_keys_str_mv AT federicadecastro nmrbasedmetabolomicsinmetalbaseddrugresearch
AT michelebenedetti nmrbasedmetabolomicsinmetalbaseddrugresearch
AT lauradelcoco nmrbasedmetabolomicsinmetalbaseddrugresearch
AT francescopaolofanizzi nmrbasedmetabolomicsinmetalbaseddrugresearch
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