NMR-Based Metabolomics in Metal-Based Drug Research
Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. I...
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doaj-393659e6a01e4bbcb41a7386b8af6bad2020-11-25T01:52:00ZengMDPI AGMolecules1420-30492019-06-012412224010.3390/molecules24122240molecules24122240NMR-Based Metabolomics in Metal-Based Drug ResearchFederica De Castro0Michele Benedetti1Laura Del Coco2Francesco Paolo Fanizzi3Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, ItalyThanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments.https://www.mdpi.com/1420-3049/24/12/2240metabolomic<sup>1</sup>H NMR Spectroscopyantitumour drugsmetal drugsplatinum drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica De Castro Michele Benedetti Laura Del Coco Francesco Paolo Fanizzi |
spellingShingle |
Federica De Castro Michele Benedetti Laura Del Coco Francesco Paolo Fanizzi NMR-Based Metabolomics in Metal-Based Drug Research Molecules metabolomic <sup>1</sup>H NMR Spectroscopy antitumour drugs metal drugs platinum drugs |
author_facet |
Federica De Castro Michele Benedetti Laura Del Coco Francesco Paolo Fanizzi |
author_sort |
Federica De Castro |
title |
NMR-Based Metabolomics in Metal-Based Drug Research |
title_short |
NMR-Based Metabolomics in Metal-Based Drug Research |
title_full |
NMR-Based Metabolomics in Metal-Based Drug Research |
title_fullStr |
NMR-Based Metabolomics in Metal-Based Drug Research |
title_full_unstemmed |
NMR-Based Metabolomics in Metal-Based Drug Research |
title_sort |
nmr-based metabolomics in metal-based drug research |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-06-01 |
description |
Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments. |
topic |
metabolomic <sup>1</sup>H NMR Spectroscopy antitumour drugs metal drugs platinum drugs |
url |
https://www.mdpi.com/1420-3049/24/12/2240 |
work_keys_str_mv |
AT federicadecastro nmrbasedmetabolomicsinmetalbaseddrugresearch AT michelebenedetti nmrbasedmetabolomicsinmetalbaseddrugresearch AT lauradelcoco nmrbasedmetabolomicsinmetalbaseddrugresearch AT francescopaolofanizzi nmrbasedmetabolomicsinmetalbaseddrugresearch |
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1724995423470354432 |