A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death

A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death

Coronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic causing a serious global public health problem. The risk of vertical transmission of SARS-CoV-2 is still debated, and the consequences of this virus on pregnant women and their fetuses remain unknown. We report a case...

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Main Authors: Daniela Eugenia Popescu, Andreea Cioca, Cezara Muresan, Dan Navolan, Arina Gui, Ovidiu Pop, Tamara Marcovici, Constantin Ilie, Marius Craina, Marioara Boia
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Medicina
Subjects:
COVID-19
coronavirus
SARS-CoV-2
pregnancy
vertical transmission
fetal death
Online Access:https://www.mdpi.com/1648-9144/57/7/667
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spelling doaj-393499e14d7c40998f3c274f3e1ac8562021-07-23T13:52:51ZengMDPI AGMedicina1010-660X1648-91442021-06-015766766710.3390/medicina57070667A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine DeathDaniela Eugenia Popescu0Andreea Cioca1Cezara Muresan2Dan Navolan3Arina Gui4Ovidiu Pop5Tamara Marcovici6Constantin Ilie7Marius Craina8Marioara Boia9Department of Neonatology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, RomaniaDepartment of Pathology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, RomaniaDepartment of Obstetrics and Gynecology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, RomaniaDepartment of Obstetrics and Gynecology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, RomaniaDepartment of Morphological Sciences, University of Oradea, Universitatii Street, No.1, 410087 Oradea, RomaniaDepartment of Pediatrics, First Pediatric Clinic, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, RomaniaDepartment of Neonatology, Regina Maria Health Network, Aristide Demetriade Street, No.1, 300088 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, RomaniaDepartment of Neonatology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, RomaniaCoronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic causing a serious global public health problem. The risk of vertical transmission of SARS-CoV-2 is still debated, and the consequences of this virus on pregnant women and their fetuses remain unknown. We report a case of pregnancy complicated with hydrops fetalis that developed 7 weeks after recovery from a mild SARS-CoV-2 infection, leading to intrauterine death of the foetus. Evidence of SARS-CoV-2 placentitis was demonstrated by the presence of viral particles in the placenta identified by immunohistochemistry. As we excluded all possible etiological factors for non-immunologic hydrops fetalis, we believe that the fetal consequences of our case are related to vertical transmission of SARS-CoV-2 virus. To the best of our knowledge, this is the second reported case in the literature of COVID-19 infection complicated with hydrops fetalis and intrauterine fetal demise.https://www.mdpi.com/1648-9144/57/7/667COVID-19coronavirusSARS-CoV-2pregnancyvertical transmissionfetal death
collection DOAJ
language English
format Article
sources DOAJ
author Daniela Eugenia Popescu
Andreea Cioca
Cezara Muresan
Dan Navolan
Arina Gui
Ovidiu Pop
Tamara Marcovici
Constantin Ilie
Marius Craina
Marioara Boia
spellingShingle Daniela Eugenia Popescu
Andreea Cioca
Cezara Muresan
Dan Navolan
Arina Gui
Ovidiu Pop
Tamara Marcovici
Constantin Ilie
Marius Craina
Marioara Boia
A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
Medicina
COVID-19
coronavirus
SARS-CoV-2
pregnancy
vertical transmission
fetal death
author_facet Daniela Eugenia Popescu
Andreea Cioca
Cezara Muresan
Dan Navolan
Arina Gui
Ovidiu Pop
Tamara Marcovici
Constantin Ilie
Marius Craina
Marioara Boia
author_sort Daniela Eugenia Popescu
title A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
title_short A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
title_full A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
title_fullStr A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
title_full_unstemmed A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death
title_sort case of covid-19 pregnancy complicated with hydrops fetalis and intrauterine death
publisher MDPI AG
series Medicina
issn 1010-660X
1648-9144
publishDate 2021-06-01
description Coronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic causing a serious global public health problem. The risk of vertical transmission of SARS-CoV-2 is still debated, and the consequences of this virus on pregnant women and their fetuses remain unknown. We report a case of pregnancy complicated with hydrops fetalis that developed 7 weeks after recovery from a mild SARS-CoV-2 infection, leading to intrauterine death of the foetus. Evidence of SARS-CoV-2 placentitis was demonstrated by the presence of viral particles in the placenta identified by immunohistochemistry. As we excluded all possible etiological factors for non-immunologic hydrops fetalis, we believe that the fetal consequences of our case are related to vertical transmission of SARS-CoV-2 virus. To the best of our knowledge, this is the second reported case in the literature of COVID-19 infection complicated with hydrops fetalis and intrauterine fetal demise.
topic COVID-19
coronavirus
SARS-CoV-2
pregnancy
vertical transmission
fetal death
url https://www.mdpi.com/1648-9144/57/7/667
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