The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein

The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein

Misfolded proteins from the endoplasmic reticulum (ER) are transported back into the cytosol for degradation via the ubiquitin-proteasome system. The human cytomegalovirus protein US11 hijacks this ER-associated protein degradation (ERAD) pathway to downregulate human leukocyte antigen (HLA) class I...

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Bibliographic Details
Main Authors: Michael L. van de Weijer, Guus H. van Muijlwijk, Linda J. Visser, Ana I. Costa, Emmanuel J. H. J. Wiertz, Robert Jan Lebbink
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Viruses
Subjects:
ER-associated protein degradation
ERAD
TMEM129
E3 ligase
topology
transmembrane
RING domain
Online Access:http://www.mdpi.com/1999-4915/8/11/309

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