Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.

Bibliographic Details
Main Authors: Konstanze T. Schiessl, Fanghao Hu, Jeanyoung Jo, Sakila Z. Nazia, Bryan Wang, Alexa Price-Whelan, Wei Min, Lars E. P. Dietrich
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08733-w
id doaj-391da8e46f344a68bdd44bdb1155726c
record_format Article
spelling doaj-391da8e46f344a68bdd44bdb1155726c2021-05-11T11:48:38ZengNature Publishing GroupNature Communications2041-17232019-02-0110111010.1038/s41467-019-08733-wPhenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilmsKonstanze T. Schiessl0Fanghao Hu1Jeanyoung Jo2Sakila Z. Nazia3Bryan Wang4Alexa Price-Whelan5Wei Min6Lars E. P. Dietrich7Department of Biological Sciences, Columbia UniversityDepartment of Chemistry, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Chemistry, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityPseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.https://doi.org/10.1038/s41467-019-08733-w
collection DOAJ
language English
format Article
sources DOAJ
author Konstanze T. Schiessl
Fanghao Hu
Jeanyoung Jo
Sakila Z. Nazia
Bryan Wang
Alexa Price-Whelan
Wei Min
Lars E. P. Dietrich
spellingShingle Konstanze T. Schiessl
Fanghao Hu
Jeanyoung Jo
Sakila Z. Nazia
Bryan Wang
Alexa Price-Whelan
Wei Min
Lars E. P. Dietrich
Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
Nature Communications
author_facet Konstanze T. Schiessl
Fanghao Hu
Jeanyoung Jo
Sakila Z. Nazia
Bryan Wang
Alexa Price-Whelan
Wei Min
Lars E. P. Dietrich
author_sort Konstanze T. Schiessl
title Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_short Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_full Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_fullStr Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_full_unstemmed Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_sort phenazine production promotes antibiotic tolerance and metabolic heterogeneity in pseudomonas aeruginosa biofilms
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-02-01
description Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.
url https://doi.org/10.1038/s41467-019-08733-w
work_keys_str_mv AT konstanzetschiessl phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT fanghaohu phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT jeanyoungjo phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT sakilaznazia phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT bryanwang phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT alexapricewhelan phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT weimin phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
AT larsepdietrich phenazineproductionpromotesantibiotictoleranceandmetabolicheterogeneityinpseudomonasaeruginosabiofilms
_version_ 1721445937401823232

Similar Items