Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript...
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doaj-391a56a2f76841a2a98a599ec56285622020-11-25T03:24:07ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492010-01-01410.4137/CMO.S6446Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case StudyWalter Kleine Neto0Mariana Serpa1Sabri Saeed Sanabani2Patricia Torres Bueno3Elvira Deolinda Rodrigues Pereira Velloso4Pedro Enrique Dorlhiac-Llacer5Israel Bendit6 Department of Translational Medicine, Federal University of São Paulo, Brazil. Cancer Institute of São Paulo, São Paulo, Brazil. Clinical Immunology and Allergy Division, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment.https://doi.org/10.4137/CMO.S6446 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walter Kleine Neto Mariana Serpa Sabri Saeed Sanabani Patricia Torres Bueno Elvira Deolinda Rodrigues Pereira Velloso Pedro Enrique Dorlhiac-Llacer Israel Bendit |
spellingShingle |
Walter Kleine Neto Mariana Serpa Sabri Saeed Sanabani Patricia Torres Bueno Elvira Deolinda Rodrigues Pereira Velloso Pedro Enrique Dorlhiac-Llacer Israel Bendit Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study Clinical Medicine Insights: Oncology |
author_facet |
Walter Kleine Neto Mariana Serpa Sabri Saeed Sanabani Patricia Torres Bueno Elvira Deolinda Rodrigues Pereira Velloso Pedro Enrique Dorlhiac-Llacer Israel Bendit |
author_sort |
Walter Kleine Neto |
title |
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study |
title_short |
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study |
title_full |
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study |
title_fullStr |
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study |
title_full_unstemmed |
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study |
title_sort |
early detection of t(8;21) chromosomal translocations during treatment of positive acute promyelocytic leukemia: a case study |
publisher |
SAGE Publishing |
series |
Clinical Medicine Insights: Oncology |
issn |
1179-5549 |
publishDate |
2010-01-01 |
description |
Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment. |
url |
https://doi.org/10.4137/CMO.S6446 |
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