Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study

Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript...

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Main Authors: Walter Kleine Neto, Mariana Serpa, Sabri Saeed Sanabani, Patricia Torres Bueno, Elvira Deolinda Rodrigues Pereira Velloso, Pedro Enrique Dorlhiac-Llacer, Israel Bendit
Format: Article
Language:English
Published: SAGE Publishing 2010-01-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.4137/CMO.S6446
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spelling doaj-391a56a2f76841a2a98a599ec56285622020-11-25T03:24:07ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492010-01-01410.4137/CMO.S6446Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case StudyWalter Kleine Neto0Mariana Serpa1Sabri Saeed Sanabani2Patricia Torres Bueno3Elvira Deolinda Rodrigues Pereira Velloso4Pedro Enrique Dorlhiac-Llacer5Israel Bendit6 Department of Translational Medicine, Federal University of São Paulo, Brazil. Cancer Institute of São Paulo, São Paulo, Brazil. Clinical Immunology and Allergy Division, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment.https://doi.org/10.4137/CMO.S6446
collection DOAJ
language English
format Article
sources DOAJ
author Walter Kleine Neto
Mariana Serpa
Sabri Saeed Sanabani
Patricia Torres Bueno
Elvira Deolinda Rodrigues Pereira Velloso
Pedro Enrique Dorlhiac-Llacer
Israel Bendit
spellingShingle Walter Kleine Neto
Mariana Serpa
Sabri Saeed Sanabani
Patricia Torres Bueno
Elvira Deolinda Rodrigues Pereira Velloso
Pedro Enrique Dorlhiac-Llacer
Israel Bendit
Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
Clinical Medicine Insights: Oncology
author_facet Walter Kleine Neto
Mariana Serpa
Sabri Saeed Sanabani
Patricia Torres Bueno
Elvira Deolinda Rodrigues Pereira Velloso
Pedro Enrique Dorlhiac-Llacer
Israel Bendit
author_sort Walter Kleine Neto
title Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
title_short Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
title_full Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
title_fullStr Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
title_full_unstemmed Early Detection of t(8;21) Chromosomal Translocations during Treatment of Positive Acute Promyelocytic Leukemia: A Case Study
title_sort early detection of t(8;21) chromosomal translocations during treatment of positive acute promyelocytic leukemia: a case study
publisher SAGE Publishing
series Clinical Medicine Insights: Oncology
issn 1179-5549
publishDate 2010-01-01
description Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment.
url https://doi.org/10.4137/CMO.S6446
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