Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coeff...

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Main Authors: Matej Velicky, Andrew Norman John Rodgers, Robert Angus William Dryfe, Kin Y Tam
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2014-09-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/22
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spelling doaj-3917ebc3bcdd4208af1db5207ca690562020-11-25T00:13:09ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182014-09-012314315610.5599/admet.2.3.2296Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugsMatej Velicky0Andrew Norman John Rodgers1Robert Angus William Dryfe2Kin Y Tam3University of ManchesterUniversity of ManchesterUniversity of ManchesterUniversity of MacauIn this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.http://pub.iapchem.org/ojs/index.php/admet/article/view/22
collection DOAJ
language English
format Article
sources DOAJ
author Matej Velicky
Andrew Norman John Rodgers
Robert Angus William Dryfe
Kin Y Tam
spellingShingle Matej Velicky
Andrew Norman John Rodgers
Robert Angus William Dryfe
Kin Y Tam
Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
ADMET and DMPK
author_facet Matej Velicky
Andrew Norman John Rodgers
Robert Angus William Dryfe
Kin Y Tam
author_sort Matej Velicky
title Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
title_short Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
title_full Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
title_fullStr Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
title_full_unstemmed Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
title_sort use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
publisher International Association of Physical Chemists (IAPC)
series ADMET and DMPK
issn 1848-7718
publishDate 2014-09-01
description In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.
url http://pub.iapchem.org/ojs/index.php/admet/article/view/22
work_keys_str_mv AT matejvelicky useofvoltammetryforinvitroequilibriumandtransportstudiesofionisabledrugs
AT andrewnormanjohnrodgers useofvoltammetryforinvitroequilibriumandtransportstudiesofionisabledrugs
AT robertanguswilliamdryfe useofvoltammetryforinvitroequilibriumandtransportstudiesofionisabledrugs
AT kinytam useofvoltammetryforinvitroequilibriumandtransportstudiesofionisabledrugs
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