Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

Abstract Background Congenital diaphragmatic hernia is an orphan disease with high neonatal mortality and significant morbidity. An important cause for this is pulmonary hypertension, for which no effective postnatal therapy is available to date. An innovative strategy aiming at treating or preventi...

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Bibliographic Details
Main Authors: Francesca Maria Russo, Alexandra Benachi, Tim Van Mieghem, Jan De Hoon, Kristel Van Calsteren, Pieter Annaert, Jean-Marc Tréluyer, Karel Allegaert, Jan Deprest
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Trials
Subjects:
Sildenafil citrate
Congenital diaphragmatic hernia
Transplacental therapy
Placenta transfer study
Online Access:http://link.springer.com/article/10.1186/s13063-018-2897-8

Internet

http://link.springer.com/article/10.1186/s13063-018-2897-8

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