Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells

Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells

Hematopoietic stem cells (HSCs) yield both the myeloid and lymphoid lineages of blood cells and can be reprogrammed into tumor antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) to prevent tumor growth. However, the optimal approach for differentiating tumor Ag-specific CTLs from HSCs, such a...

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Bibliographic Details
Main Authors: Xiaofang Xiong, Jugal Kishor Das, Jianyong Song, Bing Ni, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Vaccines
Subjects:
hematopoietic stem cells
T cells
immunotherapy
melanoma
mouse model
Online Access:http://www.mdpi.com/2076-393X/6/3/40

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