Underlying mechanisms and drug intervention strategies for the tumour microenvironment

• Main Authors: Haoze Li, Lihong Zhou, Jing Zhou, Qi Li, Qing Ji
• Format: Article
• Language: English
• Published: BMC 2021-03-01
• Series: Journal of Experimental & Clinical Cancer Research
• Subjects: TME; Cancer development; Molecular targets; Drug intervention strategies
• Online Access: https://doi.org/10.1186/s13046-021-01893-y

Abstract Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and special biological characteristics, such as hypoxia, nutrient deficiency, inflammation, immunosuppression and cytokine production. In addition, a large number of cancer-associated biomolecules and signalling pathways are involved in the above bioprocesses. This paper reviews our understanding of the TME and describes its biological and molecular characterization in different stages of cancer development. Furthermore, we discuss in detail the intervention strategies for the critical points of the TME, including chemotherapy, targeted therapy, immunotherapy, natural products from traditional Chinese medicine, combined drug therapy, etc., providing a scientific basis for cancer therapy from the perspective of key molecular targets in the TME.