Synthesis and Structural Characterization of 1- and 2-Substituted Indazoles: Ester and Carboxylic Acid Derivatives

Synthesis and Structural Characterization of 1- and 2-Substituted Indazoles: Ester and Carboxylic Acid Derivatives

A series of indazoles substituted at the N-1 and N-2 positions with ester-containing side chains -(CH2)nCO2R of different lengths (n = 0-6, 9, 10) are described.Nucleophilic substitution reactions on halo esters (X(CH2)nCO2R) by 1H-indazole inalkaline solution lead to mixtures of N-1 and N-2 isomers...

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Bibliographic Details
Main Authors: Isabel Bento, M. Teresa Duarte, M. João M. Curto, Inês F. Antunes, Hélène Ramos, Fátima C. Teixeira
Format: Article
Language:English
Published: MDPI AG 2006-11-01
Series:Molecules
Subjects:
Indazole
N-1 and N-2 isomers
Spectroscopic characterization
X-ray diffraction studies.
Online Access:http://www.mdpi.com/1420-3049/11/11/867/

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