Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation

Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation

Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7−20% of all renal tumors. Proteome and metabolome profiles of 19 pRCC and patient-matched healthy kidney controls were used to elucidate the regulation of metabolic pathways and the underlying molecula...

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Bibliographic Details
Main Authors: Ayham Al Ahmad, Vanessa Paffrath, Rosanna Clima, Jonas Felix Busch, Anja Rabien, Ergin Kilic, Sonia Villegas, Bernd Timmermann, Marcella Attimonelli, Klaus Jung, David Meierhofer
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
Papillary renal cell carcinoma (pRCC)
proteome profiling
metabolome profiling
glutathione metabolism
metabolic reprogramming
Online Access:https://www.mdpi.com/2072-6694/11/9/1298

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