Simultaneous determination of asenapine and valproic acid in human plasma using LCâMS/MS: Application of the method to support pharmacokinetic study

Simultaneous determination of asenapine and valproic acid in human plasma using LCâMS/MS: Application of the method to support pharmacokinetic study

Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders. A simple LCâMS/MS method was developed and validated for simultaneous quantification of asenapine and valproic acid in human plasma. Internal standa...

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Bibliographic Details
Main Authors:	Ambavaram Vijaya Bhaskar Reddy, Nandigam Venugopal, Gajulapalle Madhavi
Format:	Article
Language:	English
Published:	Elsevier 2013-12-01
Series:	Journal of Pharmaceutical Analysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177913000543

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