Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1

Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1

Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor invasion, metastasis, and chemoresistance. Osteopontin (OPN), a phosphorylated glycoprotein, is overexpressed in pancreatic cancer. However, OPN expression in PSCs and its potential roles in tumor–st...

Full description

Bibliographic Details
Main Authors: Junyu Cao, Jie Li, Liankang Sun, Tao Qin, Ying Xiao, Ke Chen, Weikun Qian, Wanxing Duan, Jianjun Lei, Jiguang Ma, Qingyong Ma, Liang Han
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Molecular Oncology
Subjects:
cancer stem cell‐like properties
epithelial–mesenchymal transition
hypoxia
pancreatic cancer
pancreatic stellate cells
Online Access:https://doi.org/10.1002/1878-0261.12399

Internet

https://doi.org/10.1002/1878-0261.12399

Similar Items