Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Summary: Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2 convalescent plasma (CP) are under evaluation in clinical trials. Here we explored the antibody epitope repertoire, and virus neutralizing capacity of six hCoV-2IG batches as well as nine CP against SARS-CoV-2 and emerging vari...

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Bibliographic Details
Main Authors: Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B. Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
biological sciences
immunology
immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221009743

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http://www.sciencedirect.com/science/article/pii/S2589004221009743

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