Key Role of the Membrane Trafficking of Nav1.5 Channel Protein in Antidepressant-Induced Brugada Syndrome

Key Role of the Membrane Trafficking of Nav1.5 Channel Protein in Antidepressant-Induced Brugada Syndrome

Anti-depressant treatment has been found to be associated with the development of Brugada syndrome (BrS) through poorly defined mechanisms. Herein, this study aimed to explore the molecular basis for amitriptyline-induced BrS. The effects of long-term treatments of amitriptyline on Nav1.5 were inves...

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Bibliographic Details
Main Authors: Xi Chen, Chao Zhu, Hao Zhou, Yu Zhang, Zhongqi Cai, Honglin Wu, Xiaomeng Ren, Lei Gao, Jiancheng Zhang, Yang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
Brugada syndrome
antidepressant
Nav1.5
long-term effect
trafficking
interacting proteins
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01230/full

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