Biomimetic reconstruction of the hematopoietic stem cell niche for in vitro amplification of human hematopoietic stem cells.

Biomimetic reconstruction of the hematopoietic stem cell niche for in vitro amplification of human hematopoietic stem cells.

Hematopoietic stem cell transplantation is successfully applied since the late 1950s; however, its efficacy still needs to be increased. A promising strategy is to transplant high numbers of pluripotent hematopoietic stem cells (HSCs). Therefore, an improved ex vivo culture system that supports prol...

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Bibliographic Details
Main Authors: L Marx-Blümel, C Marx, F Weise, J Frey, B Perner, G Schlingloff, N Lindig, J Hampl, J Sonnemann, D Brauer, A Voigt, S Singh, B Beck, Ute-Maria Jäger, Z Q Wang, J F Beck, A Schober
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234638

Internet

https://doi.org/10.1371/journal.pone.0234638

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