Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Abstract Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known risk factors in AD, including loss-of-function varia...

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Bibliographic Details
Main Authors: Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F. Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q. Trojanowski, Virginia M.-Y. Lee, Kurt R. Brunden
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s
Microglia
Pathology
Plaques
Tau
Online Access:https://doi.org/10.1186/s40478-021-01251-1

Internet

https://doi.org/10.1186/s40478-021-01251-1

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