Semi-supervised learning for somatic variant calling and peptide identification in personalized cancer immunotherapy
Abstract Background Personalized cancer vaccines are emerging as one of the most promising approaches to immunotherapy of advanced cancers. However, only a small proportion of the neoepitopes generated by somatic DNA mutations in cancer cells lead to tumor rejection. Since it is impractical to exper...
Main Authors: | Elham Sherafat, Jordan Force, Ion I. Măndoiu |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-12-01
|
Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12859-020-03813-x |
Similar Items
-
Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers
by: Maurizio Callari, et al.
Published: (2017-04-01) -
Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples
by: Rebecca F. Halperin, et al.
Published: (2019-03-01) -
Understanding and Improving Identification of Somatic Variants
by: Vijayan, Vinaya
Published: (2016) -
Evaluation of variant calling tools for large plant genome re-sequencing
by: Zhen Yao, et al.
Published: (2020-08-01) -
Detailed comparison of two popular variant calling packages for exome and targeted exon studies
by: Charles D. Warden, et al.
Published: (2014-09-01)