The NLRP3 inflammasome in macrophages is stimulated by cell‐free hemoglobin

The NLRP3 inflammasome in macrophages is stimulated by cell‐free hemoglobin

Abstract Cell‐free hemoglobin (CFH) is associated with severe lung injury in human patients and is sufficient to induce airspace inflammation and alveolar–capillary barrier dysfunction in an experimental model of acute lung injury. The mechanisms through which this occurs are unknown. One key pathwa...

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Bibliographic Details
Main Authors: Ciara M. Shaver, Stuart R. Landstreet, Sangamithra Pugazenthi, Fiona Scott, Nathan Putz, Lorraine B. Ware, Julie A. Bastarache
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Physiological Reports
Subjects:
acute lung injury
ARDS
cell‐free hemoglobin
inflammasome
NLRP3
Online Access:https://doi.org/10.14814/phy2.14589

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