Efficient assembly of nanopore reads via highly accurate and intact error correction
Nanopore reads have been advantageous for de novo genome assembly; however these reads have high error rates. Here, the authors develop an error correction and de novo assembly tool, NECAT, which produces efficient, high quality assemblies of nanopore reads.
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2021-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-20236-7 |
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doaj-38b07015c4a4482d87dff528f09c3e092021-01-10T12:19:23ZengNature Publishing GroupNature Communications2041-17232021-01-0112111010.1038/s41467-020-20236-7Efficient assembly of nanopore reads via highly accurate and intact error correctionYing Chen0Fan Nie1Shang-Qian Xie2Ying-Feng Zheng3Qi Dai4Thomas Bray5Yao-Xin Wang6Jian-Feng Xing7Zhi-Jian Huang8De-Peng Wang9Li-Juan He10Feng Luo11Jian-Xin Wang12Yi-Zhi Liu13Chuan-Le Xiao14State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversitySchool of Information Science and Engineering, Central South UniversityKey Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants, Ministry of Education, Hainan UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityOxford Nanopore TechnologiesCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityKey Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants, Ministry of Education, Hainan UniversitySchool of Marine Sciences, Sun Yat-sen UniversityNextomics Biosciences Co., LtdState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversitySchool of Computing, Clemson UniversitySchool of Information Science and Engineering, Central South UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityNanopore reads have been advantageous for de novo genome assembly; however these reads have high error rates. Here, the authors develop an error correction and de novo assembly tool, NECAT, which produces efficient, high quality assemblies of nanopore reads.https://doi.org/10.1038/s41467-020-20236-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Chen Fan Nie Shang-Qian Xie Ying-Feng Zheng Qi Dai Thomas Bray Yao-Xin Wang Jian-Feng Xing Zhi-Jian Huang De-Peng Wang Li-Juan He Feng Luo Jian-Xin Wang Yi-Zhi Liu Chuan-Le Xiao |
spellingShingle |
Ying Chen Fan Nie Shang-Qian Xie Ying-Feng Zheng Qi Dai Thomas Bray Yao-Xin Wang Jian-Feng Xing Zhi-Jian Huang De-Peng Wang Li-Juan He Feng Luo Jian-Xin Wang Yi-Zhi Liu Chuan-Le Xiao Efficient assembly of nanopore reads via highly accurate and intact error correction Nature Communications |
author_facet |
Ying Chen Fan Nie Shang-Qian Xie Ying-Feng Zheng Qi Dai Thomas Bray Yao-Xin Wang Jian-Feng Xing Zhi-Jian Huang De-Peng Wang Li-Juan He Feng Luo Jian-Xin Wang Yi-Zhi Liu Chuan-Le Xiao |
author_sort |
Ying Chen |
title |
Efficient assembly of nanopore reads via highly accurate and intact error correction |
title_short |
Efficient assembly of nanopore reads via highly accurate and intact error correction |
title_full |
Efficient assembly of nanopore reads via highly accurate and intact error correction |
title_fullStr |
Efficient assembly of nanopore reads via highly accurate and intact error correction |
title_full_unstemmed |
Efficient assembly of nanopore reads via highly accurate and intact error correction |
title_sort |
efficient assembly of nanopore reads via highly accurate and intact error correction |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-01-01 |
description |
Nanopore reads have been advantageous for de novo genome assembly; however these reads have high error rates. Here, the authors develop an error correction and de novo assembly tool, NECAT, which produces efficient, high quality assemblies of nanopore reads. |
url |
https://doi.org/10.1038/s41467-020-20236-7 |
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