Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation

Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation

Anaplastic thyroid carcinoma (ATC) is a tumor with bad prognosis and long-term survival is very low. However, appropriate combinations of chemotherapy, surgery, and radition have been reported to potentially improve the treatment results for ATC. We describe a case of refractory ATC successfully tre...

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Main Authors: Koji Kato, Yuju Ohno, Shoshu Mitsuyama, Satoshi Toyoshima, Junichi Ito, Hisashi Gondo, Mine Harada
Format: Article
Language:English
Published: SAGE Publishing 2007-01-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.4137/CMO.S435
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spelling doaj-38aaaded45874bef8ea3bee3b05681402020-11-25T03:43:17ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492007-01-01110.4137/CMO.S435Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell TransplantationKoji Kato0Yuju Ohno1Shoshu Mitsuyama2Satoshi Toyoshima3Junichi Ito4Hisashi Gondo5Mine Harada6Blood and Marrow Transplantation program, University of Michigan Comprehensive Cancer Center, Michigan, U.S.A.Department of Hematology, Kitakyushu Municipal Medical Center, Fukuoka, Japan.Department of Surgery, Kitakyushu Municipal Medical Center, Fukuoka, Japan.Department of Pathology, Kitakyushu Municipal Medical Center, Fukuoka, Japan.Ito Clinic, Fukuoka, Japan.Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Anaplastic thyroid carcinoma (ATC) is a tumor with bad prognosis and long-term survival is very low. However, appropriate combinations of chemotherapy, surgery, and radition have been reported to potentially improve the treatment results for ATC. We describe a case of refractory ATC successfully treated with high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). There has not been any evidence of recurrence for 10 years after auto-PBSCT. To the best of our knowledge, this is the first case of ATC that has been followed up for a long-term period after HDC with auto-PBSCT. This case suggests that intensive therapeutic approach such as HDC with auto-PBSCT may be useful.https://doi.org/10.4137/CMO.S435
collection DOAJ
language English
format Article
sources DOAJ
author Koji Kato
Yuju Ohno
Shoshu Mitsuyama
Satoshi Toyoshima
Junichi Ito
Hisashi Gondo
Mine Harada
spellingShingle Koji Kato
Yuju Ohno
Shoshu Mitsuyama
Satoshi Toyoshima
Junichi Ito
Hisashi Gondo
Mine Harada
Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
Clinical Medicine Insights: Oncology
author_facet Koji Kato
Yuju Ohno
Shoshu Mitsuyama
Satoshi Toyoshima
Junichi Ito
Hisashi Gondo
Mine Harada
author_sort Koji Kato
title Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
title_short Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
title_full Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
title_fullStr Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
title_full_unstemmed Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation
title_sort long-term remission in a case of anaplastic thyroid carcinoma following local irradiation and high-dose chemotherapy with autologous peripheral blood stem cell transplantation
publisher SAGE Publishing
series Clinical Medicine Insights: Oncology
issn 1179-5549
publishDate 2007-01-01
description Anaplastic thyroid carcinoma (ATC) is a tumor with bad prognosis and long-term survival is very low. However, appropriate combinations of chemotherapy, surgery, and radition have been reported to potentially improve the treatment results for ATC. We describe a case of refractory ATC successfully treated with high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). There has not been any evidence of recurrence for 10 years after auto-PBSCT. To the best of our knowledge, this is the first case of ATC that has been followed up for a long-term period after HDC with auto-PBSCT. This case suggests that intensive therapeutic approach such as HDC with auto-PBSCT may be useful.
url https://doi.org/10.4137/CMO.S435
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AT yujuohno longtermremissioninacaseofanaplasticthyroidcarcinomafollowinglocalirradiationandhighdosechemotherapywithautologousperipheralbloodstemcelltransplantation
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