Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines

Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines

(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acet...

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Main Authors: Fahmideh Shabani, Shahriar Ghammamy, Khayroallah Mehrani, Mohammad Bagher Teimouri, Masoud Soleimani, Saeid Kaviani
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2008/501021
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spelling doaj-389a11e2bac24d7b9c894df6824ad8c62020-11-25T01:14:46ZengHindawi LimitedBioinorganic Chemistry and Applications1565-36331687-479X2008-01-01200810.1155/2008/501021501021Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell LinesFahmideh Shabani0Shahriar Ghammamy1Khayroallah Mehrani2Mohammad Bagher Teimouri3Masoud Soleimani4Saeid Kaviani5Department of Chemistry, Islamic Azad University, Young Researchers club, Ardabil Branch, 56157-31567 Ardabil, IranDepartment of Chemistry, Faculty of Science, Imam Khomeini International University, 34149-16818 Ghazvin, IranDepartment of Chemistry, Islamic Azad University, Young Researchers club, Ardabil Branch, 56157-31567 Ardabil, IranPetrochemical Department, Iran Polymer and Petrochemical Institute, P.O. Box 14965-115, Tehran, IranDepartment of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box 14115-318, Tehran, IranDepartment of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box 14115-318, Tehran, Iran(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes. These new complexes showed excellent antitumor activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.http://dx.doi.org/10.1155/2008/501021
collection DOAJ
language English
format Article
sources DOAJ
author Fahmideh Shabani
Shahriar Ghammamy
Khayroallah Mehrani
Mohammad Bagher Teimouri
Masoud Soleimani
Saeid Kaviani
spellingShingle Fahmideh Shabani
Shahriar Ghammamy
Khayroallah Mehrani
Mohammad Bagher Teimouri
Masoud Soleimani
Saeid Kaviani
Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
Bioinorganic Chemistry and Applications
author_facet Fahmideh Shabani
Shahriar Ghammamy
Khayroallah Mehrani
Mohammad Bagher Teimouri
Masoud Soleimani
Saeid Kaviani
author_sort Fahmideh Shabani
title Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
title_short Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
title_full Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
title_fullStr Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
title_full_unstemmed Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
title_sort antitumor activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1h,3h)-dione and its ti(iv), zn(ii), fe(iii), and pd(ii) complexes on k562 and jurkat cell lines
publisher Hindawi Limited
series Bioinorganic Chemistry and Applications
issn 1565-3633
1687-479X
publishDate 2008-01-01
description (6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes. These new complexes showed excellent antitumor activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.
url http://dx.doi.org/10.1155/2008/501021
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AT khayroallahmehrani antitumoractivityof6cyclohexylamino13dimethyl52pyridylfuro23dpyrimidine241h3hdioneanditstiivzniifeiiiandpdiicomplexesonk562andjurkatcelllines
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