CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques
CRANAD-28, a difluoroboron curcumin analogue, has been demonstrated in earlier reports to successfully label amyloid beta (Aβ) plaques for imaging both ex vivo and in vivo. CRANAD-28’s imaging brightness, ability to penetrate the blood brain barrier, and low toxicity make the comp...
Main Authors: | Kathleen Ran, Jing Yang, Anil V. Nair, Biyue Zhu, Chongzhao Ran |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-02-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/4/863 |
Similar Items
-
In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice
by: Ruiqing Ni, et al.
Published: (2021-09-01) -
Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease
by: David L. Brody, et al.
Published: (2017-08-01) -
Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model
by: Christian Humpel
Published: (2021-04-01) -
Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques
by: Christian eHumpel
Published: (2015-04-01) -
Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development
by: Dominik Röhr, et al.
Published: (2020-12-01)