Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells

Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells

There is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, tha...

Full description

Bibliographic Details
Main Authors: Antunes Lusânia Maria Greggi, Takahashi Catarina Satie
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 1999-01-01
Series:Genetics and Molecular Biology
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000200015
id doaj-388b5636f6c348b4920c8746c4fe2995
record_format Article
spelling doaj-388b5636f6c348b4920c8746c4fe29952020-11-25T01:28:33ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46851999-01-01222223227Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cellsAntunes Lusânia Maria GreggiTakahashi Catarina SatieThere is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, that also induces chromosome aberrations. Rat bone marrow cells treated simultaneously with olive oil (10 ml/kg body weight) and DXR (90 mg/kg body weight) developed significantly fewer chromosomal aberrations and abnormal metaphases than those treated with DXR alone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000200015
collection DOAJ
language English
format Article
sources DOAJ
author Antunes Lusânia Maria Greggi
Takahashi Catarina Satie
spellingShingle Antunes Lusânia Maria Greggi
Takahashi Catarina Satie
Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
Genetics and Molecular Biology
author_facet Antunes Lusânia Maria Greggi
Takahashi Catarina Satie
author_sort Antunes Lusânia Maria Greggi
title Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
title_short Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
title_full Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
title_fullStr Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
title_full_unstemmed Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
title_sort olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
publisher Sociedade Brasileira de Genética
series Genetics and Molecular Biology
issn 1415-4757
1678-4685
publishDate 1999-01-01
description There is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, that also induces chromosome aberrations. Rat bone marrow cells treated simultaneously with olive oil (10 ml/kg body weight) and DXR (90 mg/kg body weight) developed significantly fewer chromosomal aberrations and abnormal metaphases than those treated with DXR alone.
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000200015
work_keys_str_mv AT antuneslusaniamariagreggi oliveoilprotectsagainstchromosomalaberrationsinducedbydoxorubicininwistarratbonemarrowcells
AT takahashicatarinasatie oliveoilprotectsagainstchromosomalaberrationsinducedbydoxorubicininwistarratbonemarrowcells
_version_ 1725100879821930496

Similar Items