The biomechanical properties of an epithelial tissue determine the location of its vasculature
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion...
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Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13560 |
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doaj-3882207bac40498da5c5335ea5cae3b02021-05-11T10:59:28ZengNature Publishing GroupNature Communications2041-17232016-12-017111210.1038/ncomms13560The biomechanical properties of an epithelial tissue determine the location of its vasculatureMartin Kragl0Rajib Schubert1Haiko Karsjens2Silke Otter3Barbara Bartosinska4Kay Jeruschke5Jürgen Weiss6Chunguang Chen7David Alsteens8Oliver Kuss9Stephan Speier10Daniel Eberhard11Daniel J. Müller12Eckhard Lammert13Department of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule ZürichDepartment of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityDepartment of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityDepartment of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityGerman Center for Diabetes Research (DZD e.V.)German Center for Diabetes Research (DZD e.V.)German Center for Diabetes Research (DZD e.V.)Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule ZürichGerman Center for Diabetes Research (DZD e.V.)German Center for Diabetes Research (DZD e.V.)Department of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule ZürichDepartment of Biology, Institute of Metabolic Physiology, Heinrich Heine UniversityVasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization.https://doi.org/10.1038/ncomms13560 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert |
| spellingShingle |
Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert The biomechanical properties of an epithelial tissue determine the location of its vasculature Nature Communications |
| author_facet |
Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert |
| author_sort |
Martin Kragl |
| title |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
| title_short |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
| title_full |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
| title_fullStr |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
| title_full_unstemmed |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
| title_sort |
biomechanical properties of an epithelial tissue determine the location of its vasculature |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-12-01 |
| description |
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization. |
| url |
https://doi.org/10.1038/ncomms13560 |
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