Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line

Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line

Matrix metalloproteinase-12 (MMP-12) has been suggested to play an important role in airway inflammatory diseases. Tumor necrosis factor-α (TNF-α ) is known to cause an upregulation of MMP-12 via an activation of activator protein-1 (AP-1) in monocytes. In the present study, we investigated the effe...

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Bibliographic Details
Main Authors: Yingyan Yu, Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319310606

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