T cell senescence and CAR-T cell exhaustion in hematological malignancies

T cell senescence and CAR-T cell exhaustion in hematological malignancies

Abstract T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence are required to increase the lifespan of human beings and to reduce the morbidity...

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Bibliographic Details
Main Authors: Dimitri Kasakovski, Ling Xu, Yangqiu Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Hematology & Oncology
Subjects:
T cells
Senescence
Hematological malignancy
T cell activation
CAR-T cells
Online Access:http://link.springer.com/article/10.1186/s13045-018-0629-x

Internet

http://link.springer.com/article/10.1186/s13045-018-0629-x

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