Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

Objective: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin. Methods: The cytotoxic properties, 50% inhibition concentration (IC50) and its co...

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Bibliographic Details
Main Authors: Rifki Febriansah, Dewi P.P. Dyaningtyas, Sarmoko, Nunuk Aries Nurulita, Edy Meiyanto, Agung Endro Nugroho
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-03-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
Hesperidin
Doxorubicin
MCF-7/Dox cells line
Apoptosis
Pgp expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2221169115301970

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