AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury.

AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury.

BACKGROUND:AMP-activated protein kinase (AMPK) is an important enzyme in regulation of cellular energy homeostasis. We have previously shown that AMPK activation by 5-aminoimidazole-4-carboxamide (AICAR) results in suppression of immune responses, indicating the pivotal role of AMPK in immune regula...

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Bibliographic Details
Main Authors:	Yuan Guo, Yi Zhang, Kai Hong, Fengyan Luo, Qiuping Gu, Nonghua Lu, Aiping Bai
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3901729?pdf=render

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