AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway

AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway

Glioblastoma multiforme (GBM) is the most common intracranial malignancy in adults with the highest degree of malignancy and mortality. Due to its nature of diffuse invasiveness and high migration, GBM lacks an effective treatment strategy and is associated with poor prognosis. SC66 is a novel AKT i...

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Bibliographic Details
Main Authors: Lun Gao, Junhui Liu, Pengfei Xu, Gang Deng, Baohui Liu, Fanen Yuan, Yinqiu Tan, Qian Sun, Yang Xu, Huikai Zhang, Yangzhi Qi, Shoumeng Han, Kun Yang, Rongxin Geng, Hongxiang Jiang, Qianxue Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
SC66
glioblastoma multiforme
epithelial-to-mesenchymal transition
proliferation
apoptosis
AKT/β-catenin pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01102/full

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