M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.

Bibliographic Details
Main Authors: Ning Huang, Donghui Zhang, Fangyuan Li, Peiyuan Chai, Song Wang, Junlin Teng, Jianguo Chen
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06990-9
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spelling doaj-3851be7caf844f9d8bb1fd9d182b4b482021-05-11T10:22:34ZengNature Publishing GroupNature Communications2041-17232018-10-019111510.1038/s41467-018-06990-9M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centrioleNing Huang0Donghui Zhang1Fangyuan Li2Peiyuan Chai3Song Wang4Junlin Teng5Jianguo Chen6Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State Key Laboratory of Membrane Biology, College of Life Sciences, Peking UniversityCiliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.https://doi.org/10.1038/s41467-018-06990-9
collection DOAJ
language English
format Article
sources DOAJ
author Ning Huang
Donghui Zhang
Fangyuan Li
Peiyuan Chai
Song Wang
Junlin Teng
Jianguo Chen
spellingShingle Ning Huang
Donghui Zhang
Fangyuan Li
Peiyuan Chai
Song Wang
Junlin Teng
Jianguo Chen
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
Nature Communications
author_facet Ning Huang
Donghui Zhang
Fangyuan Li
Peiyuan Chai
Song Wang
Junlin Teng
Jianguo Chen
author_sort Ning Huang
title M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_short M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_full M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_fullStr M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_full_unstemmed M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_sort m-phase phosphoprotein 9 regulates ciliogenesis by modulating cp110-cep97 complex localization at the mother centriole
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.
url https://doi.org/10.1038/s41467-018-06990-9
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AT donghuizhang mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
AT fangyuanli mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
AT peiyuanchai mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
AT songwang mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
AT junlinteng mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
AT jianguochen mphasephosphoprotein9regulatesciliogenesisbymodulatingcp110cep97complexlocalizationatthemothercentriole
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