Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.

Bibliographic Details
Main Authors: Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10991
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spelling doaj-384e9f53afaf4353a75ebc119a70470f2021-05-11T10:50:35ZengNature Publishing GroupNature Communications2041-17232016-03-017111810.1038/ncomms10991Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized miceIsabelle Serr0Rainer W. Fürst1Peter Achenbach2Martin G. Scherm3Füsun Gökmen4Florian Haupt5Eva-Maria Sedlmeier6Annette Knopff7Leonard Shultz8Richard A. Willis9Anette-Gabriele Ziegler10Carolin Daniel11Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenDeutsches Zentrum für Diabetesforschung (DZD)Deutsches Zentrum für Diabetesforschung (DZD)Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenInstitute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenDeutsches Zentrum für Diabetesforschung (DZD)Deutsches Zentrum für Diabetesforschung (DZD)Deutsches Zentrum für Diabetesforschung (DZD)The Jackson LaboratoryEmory Vaccine Center, NIH Tetramer Core FacilityDeutsches Zentrum für Diabetesforschung (DZD)Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenType 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.https://doi.org/10.1038/ncomms10991
collection DOAJ
language English
format Article
sources DOAJ
author Isabelle Serr
Rainer W. Fürst
Peter Achenbach
Martin G. Scherm
Füsun Gökmen
Florian Haupt
Eva-Maria Sedlmeier
Annette Knopff
Leonard Shultz
Richard A. Willis
Anette-Gabriele Ziegler
Carolin Daniel
spellingShingle Isabelle Serr
Rainer W. Fürst
Peter Achenbach
Martin G. Scherm
Füsun Gökmen
Florian Haupt
Eva-Maria Sedlmeier
Annette Knopff
Leonard Shultz
Richard A. Willis
Anette-Gabriele Ziegler
Carolin Daniel
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Nature Communications
author_facet Isabelle Serr
Rainer W. Fürst
Peter Achenbach
Martin G. Scherm
Füsun Gökmen
Florian Haupt
Eva-Maria Sedlmeier
Annette Knopff
Leonard Shultz
Richard A. Willis
Anette-Gabriele Ziegler
Carolin Daniel
author_sort Isabelle Serr
title Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_short Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_full Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_fullStr Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_full_unstemmed Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_sort type 1 diabetes vaccine candidates promote human foxp3+treg induction in humanized mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.
url https://doi.org/10.1038/ncomms10991
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