Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.
Bibliographic Details
| Main Authors: |
Isabelle Serr,
Rainer W. Fürst,
Peter Achenbach,
Martin G. Scherm,
Füsun Gökmen,
Florian Haupt,
Eva-Maria Sedlmeier,
Annette Knopff,
Leonard Shultz,
Richard A. Willis,
Anette-Gabriele Ziegler,
Carolin Daniel |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10991
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