Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons throughout the brain and spinal cord progressively degenerate resulting in muscle atrophy, paralysis and death. Recent studies using animal models of ALS implicate multiple cell-types (e.g., astrocytes and micr...

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Bibliographic Details
Main Authors: Wenting Liu, Sharmila Venugopal, Sana Majid, In Sook Ahn, Graciel Diamante, Jason Hong, Xia Yang, Scott H. Chandler
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
ALS
Motor neurons
Glial cells
Brainstem
Drop-seq
Single cell RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301522

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